IcebergSim

It is an integrated system of several statistical, methodological, and display software packages that are used to determine and display the consequences of the different decisions clinical trial lists might make about the participants, treatments, and conduct of their randomized clinical trial.
Clinical trialists simply enter the decisions and estimates they have made about the event rates they anticipate among experimental and control patients, and either the number of patients they think they can enrol or the statistical power they’d like to achieve.
But their options don’t stop there.

Users can also specify the proportions of patients they fear might be lost-to-follow-up or might not comply with their treatments.